ULTRASOUND DETECTION OF HEPATOCELLULAR CARCINOMA (HCC)
ON PATIENTS WITH CIRRHOSIS AND CHRONIC HEPATITIS: A FOLLOW-UP SURVEY FOR 5 YEARS
PHAM THI THANH XUAN, NGUYEN THIEN HUNG, PHAM THI THU THUY, MEDIC Medical Center, HCMC, VIET NAM.
Background: HCC is the most common primary liver cancer, accounting for 80% of primary liver malignant neoplasm, and 85% of HCC occur on patients with cirrhosis . Purpose: Detection of HCC and evaluating risk of HCC among patients with cirrhosis and chronic hepatitis. Methods: Cross-sectional, descriptive and retrospective study. Design: We made a follow-up survey on 198 patients with cirrhosis and chronic hepatitis by the use of ultrasound and alpha-fetoprotein (AFP) dosage every one or two months for 5 years (from October 1993 to October 1998). Results: We detected HCC in 15 patients during this period: 2 patients in the first year, 7 patients in the second year, 3 patients in the third year, 2 patients in the fourth year, and 1 patient in the fifth year. The cumulative incidence of HCC in the five year was 7.5%. The maximum size of lesion was 11 cm in diameter and the minimum one was 4 cm. Most of lesions were in the right lobe of liver and AFP dosage levels were higher than 100ng/ml. Conclusions: Periodical screening by ultrasound and AFP dosage is efficacious for detection of HCC in high-risk patients. However, it is necessary to detect HCC in small size to take part in changing patient's prognosis.