UGAP và CAP định lượng gan thấm mỡ

 

UGAP measurements UGAP measurements were performed using a LOGIQ E10 ultrasound machine (GE Healthcare, Wauwatosa, WI, USA), using a C1-6-D convex array probe. All measurements were performed in fasting conditions for more than 4 hours, on patients in a supine position, with the right arm in maximum abduction, by intercostal approach, in the right liver lobe. A large colored-coded attenuation map, automatically adjusted by the system, was positioned in the right liver lobe, in a homogenous area of the liver, free of large vessels (fig1). Using the quality map option, the best image was selected in order to acquire the attenuation coefficient measurement. Ten measurements were performed using one or two selected images of the liver and the values were automatically stored in the system. Reliable UGAP measurements were defined as the median value of 10measurements performed in a homogeneous area of liver parenchyma, with an IQR/M <0.30. UGAP values are expressed in dB/cm/ MHz or in dB/m. LOGIQ E10 ultrasound machine can also perform liver stiffness measurements for fibrosis evaluation using an accurate 2D-Shear Wave Elastography (2D-SWE) technique [20-23], but this type of evaluation was not included in the present study.

AI-guided echo helps novice nurses perform ultrasound

 By Emily Hayes, AuntMinnie.com contributing writer

February 19, 2021

Nurses with no training in ultrasound were able to acquire diagnostic-quality echocardiography images thanks to the guidance of an artificial intelligence (AI)-based software application, according to a study published February 18 in JAMA Cardiology.

In the prospective study of 240 patients at academic medical centers, nurses were able to acquire images of high quality using a commercially available software application (Caption Guidance, Caption Health) installed on a portable ultrasound system. Images were judged to be of diagnostic quality on four key endpoints: quality for ventricular size, assessment of left ventricular size and function, right ventricular size and function, and presence of pericardial effusion.

"The ability to provide echocardiography outside the traditional laboratory setting is largely limited by a lack of trained sonographers and cardiologists to acquire and interpret images," Northwestern University cardiologist Dr. James D. Thomas and colleagues noted in their report about the data. "Using this AI-based technology, individuals with no previous training may be able to obtain diagnostic echocardiographic clips of several key cardiac parameters."

The study was conducted for regulatory purposes with the U.S. Food and Drug Administration (FDA). It exceeded the requirements for accuracy and the software was cleared in February 2020 through the agency's de novo pathway for novel products.

Each nurse performed 30 scans with using the guidance software installed on a portable ultrasound scanner (uSmart 3200t Plus, Terason). The mean acquisition time was 30 minutes. Ten standard transthoracic echocardiography views were obtained for each patient.

Separately, scans were conducted by sonographers on the same ultrasound unit but without the AI guidance software. Then the diagnostic quality of the scans was independently evaluated by a panel of five expert echocardiographers.

Still images of standard transthoracic echocardiographic views acquired by a nurse using the deep-learning algorithm were judged to be of diagnostic quality. Image courtesy of Caption Health.

Per the FDA, the software needed to demonstrate diagnostic quality enabling diagnosis in at least 80% of patients on four key outcome measures. The nurses' scans were of diagnostic quality in from 92.5% to 98.8% of patients (see table), with no significant difference compared with scans by sonographers.

"Our study met all FDA-prespecified primary end points, with consistent results across [body mass index] categories and cardiac pathology, including potential distractors, such as pacemakers and prosthetic valves, with little difference between the nurse and sonographer scans," Smith and colleagues wrote.

AI-guided echocardiography, performance by nurses on four key outcome measures
Endpoint	Percent, diagnostic quality
Left ventricular size	98.8%
Global left ventricular function	98.8%
Right ventricular size	92.5%
Nontrivial pericardial effusion	98.8%

Performance of nurses was also on par with sonographers on a range of secondary endpoints. However, performance of sonographers was better than nurses when it came to determining the size of the inferior vena cava (91.5% diagnostic quality compared with 57.4%) and this is a "clear target for further algorithm development," the authors wrote.

The authors also acknowledged that limitations of the study included a relatively small number of patients and nurses and the lack of recruitment from intensive care units and emergency departments.

Smith and colleagues believe the results complement prior research, which has largely focused on the application of AI in medical imaging following the acquisition of images, as opposed to use in guiding image acquisition.

"Improvements in ultrasonography and computer hardware have led to the downsizing and cost reduction of ultrasonography machines, with handheld devices commercially available including standalone transducers interfacing with smart phones," they noted. "The [deep learning] algorithm developed in this study is relatively compact (approximately 1.5 GB) and trained on images from multiple vendors, and it therefore could be ported to work on multiple platforms."