Background & AimsGenotype 6 chronic hepatitis C (HCV) is encountered predominantly in
This investigator-initiated, open-label randomized trial was conducted in
ResultsThere was no statistical difference in SVR between 48-week and 24-week treated groups (71% vs. 60%, respectively; p = 0.24). In the 48-week and 24-week treatment groups, 81% and 80% of cases achieved rapid virological response (RVR) (p = 0.86), and 86% and 80% achieved complete early virological response (p = 0.45). Among those patients with RVR, SVR was in 86% (48-weeks), and 75% (24-weeks) of cases, whereas following non-RVR, only 8% of cases had an SVR with 48-week treatment duration.
ConclusionsOverall, RVR was achieved in the majority of genotype 6 patients and, in those patients, similar and high rates of SVR were noted following 24-week and 48-week therapy. This observation, however, needs validation in a larger study to demonstrate non-inferiority of the shorter duration therapy. In non-RVR patients, even 48-week therapy achieved low SVR rates.