Concerning our study results, when controlling for all 
factors (machines, probes, and liver volunteers in time), 
17% of inter-observer variability was due to sonographers. 
The differences in scanning procedures reported by 
healthy liver volunteers may explain why SWE values 
varied among sonographers, but the reason these scan
ning procedures varied among sonographers in the first 
place is not clear. When sonographers were debriefed 
after the study, all reported receiving training from the 
manufacturer. However, there are nuances to the protocol 
that are likely not included in the training or the consen
sus guidelines.  For example, some sonographers retain 
the first 10 SWE values they capture while others care
fully review and select their SWE values, retaining some 
and resampling others. Some sonographers tend to keep 
the lowest measurements, or the measurements with the 
least variability. Another area of potential variability is 
where the ROI is placed within the color box. It is pos
sible that these differences in sampling produced a selec
tion bias that led to differences in SWE values for some 
liver volunteers but not others (i.e., poor sampling may 
be less sensitive to the day-to-day differences within liver 
volunteers; or contrariwise, better sampling may be more 
robust to day-to-day differences occurring in liver volun
teers). That is, it is possible that by following strict pro
tocols, along with multiple resamples throughout a day, 
a more reliable measure of a person’s SWE may be ob
tained. Likewise, less strict adherence to protocols, taken 
only once, may hide true differences in SWE values and 
thus appear more reliable than they are.
Conclusion
 In conclusion, liver shear wave elastography (SWE) 
values are a function, to some degree, of the sonogra
phers obtaining these values. Caution should be used in 
interpreting SWE values, particularly when relying on 
strict thresholds for clinical decision making.

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