Thứ Năm, 27 tháng 11, 2014
A B U S and H H U S
on lesion characterization and the final assessment of automated whole breast ultrasonography
Methods: Between March and August 2012, 172 women underwent bilateral ABUS before
biopsy guided by handheld ultrasonography (HHUS) and mammography. A total of 206 breast
lesions were confirmed histopathologically by biopsy. Three-dimensional volume data from ABUS
scans were analyzed by two radiologists without the knowledge of HHUS results or patient
clinical information. The two readers described the type, shape, orientation, margin, echogenicity,
posterior acoustic features, and categorization of the final assessment of detected breast lesions.
Kappa statistics were used to analyze the described characteristics of the breast lesions detected
by both of the two readers.
Results: Of the 206 histopathologically confirmed lesions, reader 1 detected 166 lesions and
reader 2 detected 150 lesions. A total of 145 lesions were detected by both readers using ABUS
images. There was substantial agreement on shape (κ=0.707), and moderate agreement on type,
margin, mass orientation, echogenicity, and posterior acoustic features (κ=0.592, 0.438, 0.472,
0.524, and 0.541, respectively). Breast Imaging Reporting and Data System final assessment
values yielded a kappa value of 0.3971 when category subdivisions 4A, 4B, and 4C were
included. With respect to the C2, C3, C4, and C5 categories, the interobserver agreement was
Conclusion: ABUS is a promising diagnostic tool with a good interobserver agreement,
comparable to that of HHUS.
Keywords: Breast; Ultrasonography; Observer variation