Concerning our study results, when controlling for all
factors (machines, probes, and liver volunteers in time),
17% of inter-observer variability was due to sonographers.
The differences in scanning procedures reported by
healthy liver volunteers may explain why SWE values
varied among sonographers, but the reason these scan
ning procedures varied among sonographers in the first
place is not clear. When sonographers were debriefed
after the study, all reported receiving training from the
manufacturer. However, there are nuances to the protocol
that are likely not included in the training or the consen
sus guidelines. For example, some sonographers retain
the first 10 SWE values they capture while others care
fully review and select their SWE values, retaining some
and resampling others. Some sonographers tend to keep
the lowest measurements, or the measurements with the
least variability. Another area of potential variability is
where the ROI is placed within the color box. It is pos
sible that these differences in sampling produced a selec
tion bias that led to differences in SWE values for some
liver volunteers but not others (i.e., poor sampling may
be less sensitive to the day-to-day differences within liver
volunteers; or contrariwise, better sampling may be more
robust to day-to-day differences occurring in liver volun
teers). That is, it is possible that by following strict pro
tocols, along with multiple resamples throughout a day,
a more reliable measure of a person’s SWE may be ob
tained. Likewise, less strict adherence to protocols, taken
only once, may hide true differences in SWE values and
thus appear more reliable than they are.
Conclusion
In conclusion, liver shear wave elastography (SWE)
values are a function, to some degree, of the sonogra
phers obtaining these values. Caution should be used in
interpreting SWE values, particularly when relying on
strict thresholds for clinical decision making.
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